Description

2-Chloro-4-Fluoro-5-Methoxyphenylboronic Acid CAS NO 1256355-46-0 is a high-purity, multi-functional boronic acid derivative serving as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for constructing complex, fluorinated and methoxylated biaryl structures.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Diagnostic Reagent Manufacturing: Used in the production of probes and sensors for biochemical assays.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Methoxyphenylboronic Acid
CAS No.	1256355-46-0
Molecular Formula	C7H7BClFO3
Molecular Weight	203.39 g/mol
Synonyms	(2-Chloro-4-fluoro-5-methoxyphenyl)boronic acid; 2-Chloro-4-fluoro-5-methoxybenzeneboronic acid; 5-Methoxy-2-chloro-4-fluorophenylboronic acid; Boronic acid, B-(2-chloro-4-fluoro-5-methoxyphenyl)-; 1256355-46-0; 2-Cl-4-F-5-MeO-PhB(OH)2
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Fluoro-5-Methoxyphenylboronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.