Description

2-Amino-5-Fluorophenylboronic Acid, HCl is a high-purity, functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a protected amino group, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting specific receptors or enzymes.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds in the construction of biaryl structures, a common motif in medicinal chemistry.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors for diagnostic and research applications.
• Process Chemistry & Scale-Up: Suitable for optimization and kilogram-scale production of target compounds under GMP-like conditions.

Basic Information

Product Name	2-Amino-5-Fluorophenylboronic Acid, HCl
CAS No.	1256355-45-9
Molecular Formula	C6H8BFNO2 • HCl
Molecular Weight	189.40 g/mol (Free base); 225.86 g/mol (HCl salt)
Synonyms	(2-Amino-5-fluorophenyl)boronic acid hydrochloride; 5-Fluoro-2-aminophenylboronic acid HCl; 2-Amino-5-fluorobenzeneboronic acid hydrochloride; B-(2-Amino-5-fluorophenyl)boronic acid HCl salt; 2-Fluoro-5-boronylaniline hydrochloride; 5-Fluoroanthranilic acid boronic ester derivative HCl
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Fluorophenylboronic Acid, HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.