Description

4-Amino-3-Fluorophenylboronic Acid, Hydrochloride is a high-purity, functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions, and the aromatic amine provides a handle for further derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting kinase inhibition and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its fluorine and boronic acid groups for bioactivity.
• Material Science: Building block for creating advanced organic frameworks, polymers, and liquid crystals where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality makes it an ideal coupling partner for forming carbon-carbon bonds with aryl halides, a cornerstone reaction in medicinal chemistry.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of molecular probes and sensors.
• Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	4-Amino-3-Fluorophenylboronic Acid, Hydrochloride
CAS No.	1256355-32-4
Molecular Formula	C6H8BClFNO2
Molecular Weight	191.40 g/mol
Synonyms	(4-Amino-3-fluorophenyl)boronic acid hydrochloride; 3-Fluoro-4-aminophenylboronic acid HCl; 4-Amino-3-fluorobenzeneboronic acid hydrochloride; B-(4-Amino-3-fluorophenyl)boronic acid hydrochloride; 4-Amino-3-fluoro-benzeneboronic acid hydrochloride salt; 3-Fluoro-4-aminobenzeneboronic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Fluorophenylboronic Acid, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade materials for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.