Description

2-Fluoro-5-Phenoxyphenylboronic Acid is a high-purity organoboron compound, specifically a boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, as well as in materials science for creating advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex biaryl or heterobiaryl motifs for therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated phenoxy-phenyl structures.
• Material Science Research: Building block for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) where its structural properties can tune electronic characteristics.
• Suzuki-Miyaura Cross-Coupling: A fundamental reagent in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds between aryl or heteroaryl groups.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and sensors that leverage boronic acid chemistry for detecting biological analytes.
• Ligand Synthesis for Catalysis: Serves as a starting material for preparing sophisticated ligands used in homogeneous catalysis.

Basic Information

Product Name	2-Fluoro-5-Phenoxyphenylboronic Acid
CAS No.	1256355-01-7
Molecular Formula	C12H10BFO3
Molecular Weight	232.02 g/mol
Synonyms	(2-Fluoro-5-phenoxyphenyl)boronic Acid; 2-Fluoro-5-phenoxybenzeneboronic Acid; 5-Phenoxy-2-fluorophenylboronic Acid; B-(2-Fluoro-5-phenoxyphenyl)boronic Acid; 2-Fluoro-5-phenoxy-phenylboronic acid; Boronic acid, B-(2-fluoro-5-phenoxyphenyl)-; CAS 1256355-01-7
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Phenoxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.