Description

3-Butoxy-4-Chloro-2-Fluorophenylboronic Acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing complex fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated biphenyl scaffolds.
• Material Science Research: Building block for creating organic electronic materials, liquid crystals, and advanced polymers via palladium-catalyzed cross-coupling.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.

Basic Information

Product Name	3-Butoxy-4-Chloro-2-Fluorophenylboronic Acid
CAS No.	1256346-25-4
Molecular Formula	C₁₀H₁₃BClFO₃
Molecular Weight	245.47 g/mol
Synonyms	(3-Butoxy-4-chloro-2-fluorophenyl)boronic acid; 4-Chloro-3-butoxy-2-fluorobenzeneboronic acid; 2-Fluoro-4-chloro-3-butoxyphenylboronic acid; Boronic acid, B-(3-butoxy-4-chloro-2-fluorophenyl)-; 1256346-25-4; 3-n-Butoxy-4-chloro-2-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Butoxy-4-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 97% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and our quality systems support development under cGMP guidelines when required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.