Description

4-Chloro-2-Fluoro-3-Isopropoxyphenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific halogenated aromatic frameworks.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the development of molecular probes and sensors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical producers for bespoke synthesis projects requiring high-fidelity boronic acid reagents.
• Academic & Industrial R&D: A valuable tool for methodological development in catalysis and new synthetic route exploration.

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Isopropoxyphenylboronic Acid
CAS No.	1256346-21-0
Molecular Formula	C9H11BClFO3
Molecular Weight	231.45 g/mol
Synonyms	(4-Chloro-2-fluoro-3-isopropoxyphenyl)boronic acid; 2-Fluoro-4-chloro-3-isopropoxybenzeneboronic acid; 3-Isopropoxy-4-chloro-2-fluorophenylboronic acid; 4-Chloro-2-fluoro-3-(1-methylethoxy)benzeneboronic acid; Boronic acid, B-(4-chloro-2-fluoro-3-isopropoxyphenyl)-; CAS 1256346-21-0; 4-Chloro-2-fluoro-3-isopropoxybenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-Isopropoxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.