Description

4-Chloro-3-Ethoxy-2-Fluorophenylboronic Acid is a high-purity boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its role as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides with specific activity profiles.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: A key raw material for fine chemical custom synthesis and scale-up services for industrial clients.

Basic Information

Product Name	4-Chloro-3-Ethoxy-2-Fluorophenylboronic Acid
CAS No.	1256346-20-9
Molecular Formula	C8H9BClFO3
Molecular Weight	217.42 g/mol
Synonyms	(4-Chloro-3-ethoxy-2-fluorophenyl)boronic acid; 2-Fluoro-4-chloro-3-ethoxyphenylboronic acid; 4-Chloro-3-ethoxy-2-fluorobenzeneboronic acid; B-(4-Chloro-3-ethoxy-2-fluorophenyl)boronic acid; 1256346-20-9; 4-Chloro-3-ethoxy-2-fluorophenyl-Boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Ethoxy-2-Fluorophenylboronic Acid is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee it meets the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.