Description

3-Ethoxy-5-(Trifluoromethoxy)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative used as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both ethoxy and trifluoromethoxy substituents, makes it an essential reagent for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring the 3-ethoxy-5-(trifluoromethoxy)phenyl moiety to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances lipophilicity and biological activity.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures central to many functional materials and drugs.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Materials Science Research: A building block for organic electronic materials, such as those used in OLEDs and semiconductors, where its substituents fine-tune electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes.

Basic Information

Product Name	3-Ethoxy-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1256345-87-5
Molecular Formula	C9H10BF3O4
Molecular Weight	250.00 g/mol
Synonyms	[3-Ethoxy-5-(trifluoromethoxy)phenyl]boronic acid; 3-Ethoxy-5-(trifluoromethoxy)benzeneboronic acid; Boronic acid, B-[3-ethoxy-5-(trifluoromethoxy)phenyl]-; 1256345-87-5; 3-Ethoxy-5-trifluoromethoxy phenylboronic acid; 3-Ethoxy-5-(trifluoromethoxy)phenyl-B(OH)2; 5-Ethoxy-3-(trifluoromethoxy)phenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-5-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, NMR) are provided to guarantee specification compliance and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.