Description

Monolithium 3-Methylpyridine-2-Boronate is a specialized organometallic reagent featuring a lithium-boron bond stabilized by a pyridine-derived heterocycle. This compound matters as a versatile building block in modern synthetic chemistry, enabling precise carbon-boron bond formation for applications in pharmaceuticals and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a key boronate ester coupling partner for the synthesis of biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a critical precursor in the development of drug candidates, particularly those containing functionalized pyridine or bipyridine cores.
• Agrochemical Research: Used in the creation of novel herbicides and fungicides that require specific boron-containing heterocyclic motifs.
• Ligand and Catalyst Development: Employed in the synthesis of novel N,B-chelating ligands for transition metal catalysis.
• Materials Science & OLEDs: A building block for electron-transport materials and emissive layer components in organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized to create boron-labeled molecules for imaging, diagnostics, and Boron Neutron Capture Therapy (BNCT) research.

Basic Information

Product Name	Monolithium 3-Methylpyridine-2-Boronate
CAS No.	1256345-65-9
Molecular Formula	C6H7BBLiNO2
Molecular Weight	146.89 g/mol
Synonyms	2-(Lithiooxy)-3-methylpyridine-1-boronic acid cyclic ester; 3-Methylpyridine-2-boronic acid, lithium salt; Lithium 3-methylpyridine-2-boronates; 2-Lithiooxy-3-methyl-1,2-oxaborolane; Monolithium 3-methyl-2-pyridylboronate; 3-Methyl-2-pyridylboronic acid lithium salt; 1,2-Oxaborolane, 2-lithiooxy-3-methyl-
EINECS	Contact for details

Quality Control

Our Monolithium 3-Methylpyridine-2-Boronate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including NMR (¹H, ¹¹B, ¹³C), HPLC for purity assessment, and titration for active lithium content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and air-sensitive nature (easily oxidized), this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Active Li Content)	Contact for details
Solubility	Soluble in THF, DME, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.