Description

2-Fluoro-6-Hydroxyphenylboronic Acid is a multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions, and the phenolic hydroxyl group provides a handle for further derivatization. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring a fluorinated aromatic scaffold for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorine atom and phenolic group contribute to target specificity and environmental persistence.
• Ligand for Catalysis: Can be utilized to develop novel ligands for transition metal catalysts used in asymmetric synthesis and other specialized organic transformations.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of boron-containing polymers, resins, and sensors.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes, leveraging its ability to form reversible bonds with diols.
• Library Synthesis for Drug Discovery: A valuable scaffold in combinatorial chemistry and high-throughput screening for generating diverse compound libraries.

Basic Information

Product Name	2-Fluoro-6-Hydroxyphenylboronic Acid
CAS No.	1256345-60-4
Molecular Formula	C6H6BFO3
Molecular Weight	155.92 g/mol
Synonyms	(2-Fluoro-6-hydroxyphenyl)boronic acid; 2-Fluoro-6-hydroxybenzeneboronic acid; B-(2-Fluoro-6-hydroxyphenyl)boronic acid; 2-Fluoro-6-hydroxy phenylboronic acid; 2-Fluoro-6-Hydroxybenzeneboronic Acid; 1256345-60-4; 2-Fluoro-6-Hydroxy Phenyl Boronic Acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.