Description

3-Isopropoxy-5-Trifluoromethylphenylboronic Acid is a high-value organoboron reagent featuring a trifluoromethyl and an isopropoxy substituent on the aromatic ring. This compound is essential for modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, where it serves as a key building block for introducing functionalized aryl groups. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the unique properties of the trifluoromethyl group improve product efficacy.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise aromatic structures are required.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed C-C bond formation to create biaryl structures.
• Chemical Biology & Medicinal Chemistry: Facilitates the creation of molecular probes and library compounds for drug discovery and target identification.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses producing specialized intermediates for client R&D projects.

Basic Information

Item	Details
Product Name	3-Isopropoxy-5-Trifluoromethylphenylboronic Acid
CAS No.	1256345-44-4
Molecular Formula	C10H12BF3O3
Molecular Weight	248.01 g/mol
Synonyms	[3-(1-Methylethoxy)-5-(trifluoromethyl)phenyl]boronic acid; 3-Isopropoxy-5-(trifluoromethyl)benzeneboronic acid; 3-(Trifluoromethyl)-5-isopropoxyphenylboronic acid; Boronic acid, B-[3-(1-methylethoxy)-5-(trifluoromethyl)phenyl]-; 5-Isopropoxy-3-trifluoromethylphenylboronic acid; (3-Isopropoxy-5-trifluoromethylphenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 3-Isopropoxy-5-Trifluoromethylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.