Description

8-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to accelerate the discovery and production of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of carbon-carbon bonds between aryl halides and this boronic ester pinacol ester, essential for creating complex molecular architectures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science & OLED Development: Serves as a precursor for synthesizing organic semiconductors, fluorescent dyes, and electron-transport materials used in electronic devices.
• Chemical Biology & Probe Synthesis: Facilitates the creation of labeled compounds and molecular probes for biochemical assays and diagnostic applications.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the cost-effective manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	8-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine
CAS No.	1256255-96-5
Molecular Formula	C16H21BFNO3
Molecular Weight	305.15 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-fluoro-3,4-dihydro-2H-1,4-benzoxazine; 8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester; 8-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine; 8-Fluoro-6-(pinacolboronato)-3,4-dihydro-2H-1,4-benzoxazine; 8-Fluoro-6-(pinacolatoboryl)-3,4-dihydro-2H-benzo[b][1,4]oxazine; 1256255-96-5; 8-Fluoro-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine
EINECS	Contact for details

Quality Control

Our 8-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting cGMP and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.