Description

3,3-Difluoro-5-Hydroxypiperidin-2-One is a high-value, fluorinated heterocyclic building block of significant interest in modern synthetic chemistry. Its unique structure, featuring both a hydroxypiperidine core and difluoromethylene groups, makes it a versatile intermediate for constructing complex molecules with enhanced physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in protease inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve metabolic stability and bioavailability.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with unique surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring fluorinated piperidine derivatives.

Basic Information

Product Name	3,3-Difluoro-5-Hydroxypiperidin-2-One
CAS No.	1256080-98-4
Molecular Formula	C5H7F2NO2
Molecular Weight	151.11 g/mol
Synonyms	5-Hydroxy-3,3-difluoropiperidin-2-one; 3,3-Difluoro-5-hydroxypiperidin-2-one; 2-Oxo-3,3-difluoro-5-hydroxypiperidine; 3,3-Difluoro-5-hydroxy-2-piperidinone; 5-Hydroxy-3,3-difluoro-2-piperidinone; 1256080-98-4; 3,3-Difluoro-5-hydroxypiperidinone
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Production of 3,3-Difluoro-5-Hydroxypiperidin-2-One adheres to current Good Manufacturing Practices (cGMP) where applicable, ensuring batch-to-batch consistency and reliability. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the exacting standards of our global pharmaceutical and research partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.