Description

Dbco-Amine CAS NO 1255942-06-3 is a high-purity, bifunctional linker molecule featuring a strained alkyne (dibenzocyclooctyne, DBCO) and a primary amine group. This compound is essential for bioorthogonal click chemistry, enabling rapid, catalyst-free, and selective conjugation under mild physiological conditions. It is a critical reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, facilitating the labeling and crosslinking of biomolecules, nanoparticles, and polymers.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific labeling of proteins, antibodies, and peptides for therapeutic and diagnostic applications.
• Probe and Sensor Synthesis: Construction of fluorescent, biotinylated, or other functional probes for imaging and detection assays.
• Polymer and Biomaterial Functionalization: Modification of surfaces, hydrogels, and nanoparticles to introduce bioactive amine handles for further coupling.
• Chemical Biology and Proteomics: Tool for studying biomolecular interactions, pull-down assays, and activity-based protein profiling.
• Diagnostic Kit Manufacturing: Key component in the development of lateral flow assays, ELISA kits, and other in vitro diagnostic platforms.
• Pre-targeting Strategies in Radioimmunotherapy: Enables multi-step targeting approaches for improved tumor localization and reduced off-target effects.

Basic Information

Product Name	Dbco-Amine
CAS No.	1255942-06-3
Molecular Formula	C17H15NO
Molecular Weight	249.31 g/mol
Synonyms	DBCO-NH2; DBCO-Amine; 1-Amino-13,14-dioxa-5-aza-1(2,4)-pyridina-4(1,3)-benzenacyclotetradecaphane; Dibenzocyclooctylamine; Dibenzocyclooctyne-amine; Azadibenzocyclooctyne-amine; ADIBO-amine; Amine-PEG4-DBCO (related derivative).
EINECS	Contact for details

Quality Control

Our Dbco-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive click chemistry applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.