Description

n-(6-Aminocaproyl)Azadibenzocyclooctyne is a specialized bifunctional linker reagent featuring a terminal amine and a bioorthogonal azadibenzocyclooctyne (ADIBO) group. This compound is critical for enabling click chemistry-based bioconjugation strategies, allowing for the efficient, selective, and catalyst-free labeling of biomolecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and diagnostic assay production to create stable, site-specific conjugates for drug delivery, imaging, and analytical applications.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of cytotoxic payloads, fluorophores, or other functional molecules to antibodies and proteins.
• Proteomics and Biomarker Discovery: Labeling of glycoproteins, peptides, and other biomolecules for mass spectrometry analysis and pull-down assays.
• Diagnostic Reagent Manufacturing: Production of enzyme-linked immunosorbent assay (ELISA) kits, lateral flow assays, and other diagnostic tools requiring stable protein conjugates.
• Live-Cell Imaging and Tracking: Labeling of cell surface proteins or metabolites for real-time visualization without interfering with native biological processes.
• Polymer and Material Science Functionalization: Modification of nanoparticles, hydrogels, and surfaces with bioactive ligands for targeted delivery or sensing applications.
• Chemical Biology Tool Development: Synthesis of activity-based probes and other research tools for studying enzyme function and metabolic pathways.

Basic Information

Product Name	n-(6-Aminocaproyl)Azadibenzocyclooctyne
CAS No.	1255942-05-2
Molecular Formula	C22H23N3O
Molecular Weight	345.44 g/mol
Synonyms	6-((Azadibenzocyclooctyn-1-yl)amino)-6-oxohexan-1-aminium; ADIBO-NHS Ester precursor; Amino-PEG5-ADIBO (related); DBCO-PEG5-Amine (related); 1-Amino-6-(1,8-diazacycloocta-2,4,6-triyn-1-yl)-6-oxohexane; BCN-Amine linker; Bifunctional ADIBO linker; Azadibenzocyclooctyne-PEG5-Amine
EINECS	Contact for details

Quality Control

Our n-(6-Aminocaproyl)Azadibenzocyclooctyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.