Description

R-Mva-Li is a specialized organolithium reagent, a chiral building block of significant interest in advanced synthetic chemistry. Its value lies in enabling the stereoselective introduction of the (R)-3-methylvaleric acid moiety, a key structural feature in complex molecule synthesis. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Critical for the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly those requiring chiral, branched alkyl chains.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of chiral ligands and organometallic catalysts used in asymmetric catalysis.
• Fine Chemical and Flavor/Fragrance Building Block: Employed in the synthesis of complex natural products, flavors, and aroma chemicals where stereochemistry dictates organoleptic properties.
• Material Science Research: Applied in the development of novel polymers and functional materials with tailored chiral centers.
• Process Development and Scale-up: A key reagent for optimizing synthetic routes from laboratory to pilot plant and commercial production scales.

Basic Information

Product Name	R-Mva-Li
CAS No.	1255502-07-8
Molecular Formula	C6H11LiO2
Molecular Weight	122.10 g/mol
Synonyms	(R)-3-Methylvaleric acid lithium salt; (R)-3-Methylpentanoic acid lithium salt; Lithium (R)-3-methylvalerate; (R)-3-MVA-Li; (R)-β-Methylvaleric acid lithium salt; (R)-3-Methylpentanoate lithium; R-Methylvaleric acid lithium salt
EINECS	Contact for details

Quality Control

Our R-Mva-Li is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC/NMR), residual solvent content, and moisture (Karl Fischer). We adhere to cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and strong alkali nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from moisture, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.