Description

4-Fluoro(Phenyl-D4)-Boronic Acid is a deuterated derivative of 4-fluorophenylboronic acid, where four hydrogen atoms on the phenyl ring are replaced with deuterium. This compound is a crucial building block in modern synthetic chemistry, particularly valued for its role in creating isotopically labeled molecules for advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and material science industries for applications in Suzuki-Miyaura cross-coupling reactions, where it serves as a key precursor for synthesizing complex, deuterated compounds used in drug discovery, metabolic studies, and analytical standards.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of deuterated active pharmaceutical ingredients (APIs) for drug discovery and development, enhancing metabolic stability and enabling pharmacokinetic studies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for forming carbon-carbon bonds to create complex, fluorinated, and deuterated aromatic compounds.
• Isotope Labeling: Used to incorporate stable deuterium isotopes into target molecules for use as internal standards in mass spectrometry (LC-MS, GC-MS) and NMR spectroscopy.
• Agrochemical Research: Employed in the development of novel, labeled pesticides and herbicides to study environmental fate, metabolism, and degradation pathways.
• Material Science: A building block for creating specialized polymers, liquid crystals, and organic electronic materials with modified properties.
• Chemical Biology Probes: Facilitates the creation of deuterium-labeled probes for tracking biological processes and protein interactions.

Basic Information

Product Name	4-Fluoro(Phenyl-D4)-Boronic Acid
CAS No.	1254771-90-8
Molecular Formula	C6D4FB(OH)2
Molecular Weight	143.97 g/mol
Synonyms	(4-Fluorophenyl-d4)boronic Acid; 4-Fluorophenyl-d4-boronic Acid; (4-Fluoro-2,3,5,6-tetradeuteriophenyl)boronic Acid; B-(4-Fluorophenyl-d4)boronic Acid; 4-F-D4-PhB(OH)2; p-Fluoro(phenyl-d4)boronic Acid; 4-Fluorobenzene-d4-1-boronic Acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro(Phenyl-D4)-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹¹B, ¹³C), HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures the material meets the high standards required for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and handled under inert atmosphere (argon or nitrogen) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.