Description

4-Chloro-2-Fluoro-3-(Methoxycarbonyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecules. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific halogenated aromatic structures.
• Material Science: Precursor for creating functional polymers, liquid crystals, and organic electronic materials through palladium-catalyzed coupling.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic pathways and novel compound libraries.
• Suzuki-Miyaura Cross-Coupling: Specifically employed as the boronic acid component in palladium-catalyzed cross-coupling with aryl/vinyl halides.
• Complex Molecule Construction: Facilitates the synthesis of biaryl and heterobiaryl structures that are difficult to access via other methods.

Basic Information

Item	Details
Product Name	4-Chloro-2-Fluoro-3-(Methoxycarbonyl)Phenylboronic Acid
CAS No.	1254701-01-3
Molecular Formula	C8H7BClFO4
Molecular Weight	231.40 g/mol
Synonyms	(4-Chloro-2-fluoro-3-methoxycarbonylphenyl)boronic acid; 3-Borono-4-chloro-2-fluorobenzoic acid methyl ester; Methyl 3-borono-4-chloro-2-fluorobenzoate; 4-Chloro-2-fluoro-3-(methoxycarbonyl)benzeneboronic acid; 4-Chloro-2-fluoro-3-carbomethoxybenzeneboronic acid; Methyl 4-chloro-2-fluoro-3-boronobenzoate
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-(Methoxycarbonyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.