Description

3,3-Difluoro-n-Methoxy-n-Methylcyclobutane-1-Carboxamide is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutane core with fluorine and amide functionalities. This compound is valued for its role in modulating the physicochemical properties and metabolic stability of target molecules in drug discovery. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and inflammation.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluorocyclobutane moiety can enhance biological activity and environmental stability.
• Chemical Biology Probe: Serves as a versatile scaffold for creating chemical probes to study enzyme function and protein-ligand interactions in biological systems.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced materials requiring fluorinated cyclic structures for specific thermal or chemical resistance properties.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of active pharmaceutical ingredients (APIs) for clinical trials.

Basic Information

Product Name	3,3-Difluoro-n-Methoxy-n-Methylcyclobutane-1-Carboxamide
CAS No.	1254223-51-2
Molecular Formula	C8H13F2NO2
Molecular Weight	193.19 g/mol
Synonyms	3,3-Difluoro-N-methoxy-N-methylcyclobutane-1-carboxamide; 3,3-Difluoro-N-methoxy-N-methylcyclobutanecarboxamide; 1-Carboxamide, 3,3-difluoro-N-methoxy-N-methylcyclobutane-; N-Methoxy-N-methyl-3,3-difluorocyclobutanecarboxamide; 3,3-Difluorocyclobutanecarboxylic acid N-methoxy-N-methylamide
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-n-Methoxy-n-Methylcyclobutane-1-Carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.