Description

4-Bromo-2-Chloro-3-Methylbenzonitrile is a high-purity halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for constructing fused heterocyclic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a precursor for functionalized organic materials, including liquid crystals and organic semiconductors.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and pharmacological studies.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination due to the bromo and chloro substituents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of proprietary compounds for clients.

Basic Information

Product Name	4-Bromo-2-Chloro-3-Methylbenzonitrile
CAS No.	1254034-53-1
Molecular Formula	C8H5BrClN
Molecular Weight	230.49 g/mol
Synonyms	2-Chloro-4-bromo-3-methylbenzonitrile; 3-Methyl-4-bromo-2-chlorobenzonitrile; Benzonitrile, 4-bromo-2-chloro-3-methyl-; 4-Bromo-2-chloro-3-methyl-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-3-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.