Description

4-Bromo-1-Difluoromethyl-2-Methoxy-Benzene is a high-value, multi-functional aromatic building block characterized by its unique bromine and difluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications in cross-coupling reactions and as a precursor for complex fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Material Science: Serves as a monomer or precursor for advanced polymers and liquid crystals, where the benzene core and halogen/fluorine atoms contribute to desired thermal and optical properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorination on molecular conformation and interaction in medicinal chemistry.
• Organic Synthesis Building Block: Employed in multi-step syntheses to create complex, fluorinated organic molecules for various high-value chemical applications.

Basic Information

Item	Detail
Product Name	4-Bromo-1-Difluoromethyl-2-Methoxy-Benzene
CAS No.	1254034-35-9
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-Methoxy-4-bromobenzylidene difluoride; 4-Bromo-2-methoxybenzaldehyde difluoride; 1-Bromo-4-(difluoromethyl)-2-methoxybenzene; 4-Bromo-α,α-difluoro-2-methoxytoluene; 2-Methoxy-4-bromo-α,α-difluorotoluene; 4-Bromo-2-methoxybenzylidene difluoride; (4-Bromo-2-methoxyphenyl)difluoromethane
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Difluoromethyl-2-Methoxy-Benzene is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.