Description

n-Fmoc-2,5-Difluoro-D-Phenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing fluorinated aromatic side chains into peptide sequences, which can significantly enhance metabolic stability, binding affinity, and membrane permeability. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing novel therapeutics, including protease inhibitors, receptor agonists/antagonists, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of complex fluorinated peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of new drug candidates where fluorination is used to optimize pharmacokinetic and pharmacodynamic properties.
• Peptidomimetics Design: Incorporation into peptide backbones to create stable mimetics that resist enzymatic degradation.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides for studying protein-protein interactions and cellular processes.
• API Intermediate Manufacturing: Serves as a chiral building block in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Material Science: Potential use in creating specialized polymers and biomaterials with unique surface properties.

Basic Information

Item	Detail
Product Name	n-Fmoc-2,5-Difluoro-D-Phenylalanine
CAS No.	1253792-21-0
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-2,5-Difluoro-D-Phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,5-difluorophenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,5-difluoro-D-phenylalanine; N-α-Fmoc-2,5-difluoro-D-phenylalanine; Fmoc-D-2,5-Dif-Phe-OH; Fmoc-2,5-F2-D-Phe-OH; BOC Sciences Brand Product BLD-1253792-21-0
EINECS	Contact for details

Quality Control

Every batch of n-Fmoc-2,5-Difluoro-D-Phenylalanine is manufactured under strict quality management systems. We guarantee high chemical purity and chiral integrity, supported by comprehensive analytical testing including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with each shipment to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.