Description

1-(tert-Butoxycarbonyl)-6-Methylpiperidine-3-Carboxylic Acid is a high-purity, protected piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for pharmaceutical research and development, particularly in the construction of complex molecules for drug discovery programs. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce chiral, functionalized piperidine scaffolds into target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting neurological disorders, pain management, and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel bioactive compounds containing a 6-methylpiperidine moiety.
• Peptidomimetics & PROTACs: Serves as a constrained amino acid analog or a linker component in the design of peptide mimics and proteolysis-targeting chimeras.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and pesticides.
• Ligand & Catalyst Development: Building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	1-(tert-Butoxycarbonyl)-6-Methylpiperidine-3-Carboxylic Acid
CAS No.	1253200-91-7
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	6-Methyl-3-piperidinecarboxylic acid 1-(1,1-dimethylethyl) ester; 1-Boc-6-methylpiperidine-3-carboxylic acid; tert-Butyl 6-methyl-3-carboxypiperidine-1-carboxylate; 1-N-Boc-6-methylnipecotic acid; (3S)-1-(tert-Butoxycarbonyl)-6-methylpiperidine-3-carboxylic acid (for enantiopure form); 1-Boc-6-methyl-3-piperidinecarboxylic acid; 6-Methyl-1-N-Boc-nipecotic acid
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-6-Methylpiperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis (where applicable), and identity confirmation by NMR and IR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances. Our quality commitment ensures material suitability for research and development under non-GMP and cGMP (upon request) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants and storing under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.