Description

Ent-Eletriptan CAS NO 1252673-29-2 is the enantiomerically pure form of the active pharmaceutical ingredient eletriptan, a potent and selective serotonin (5-HT1B/1D) receptor agonist. This high-purity chiral intermediate is critical for the research and development of novel therapeutic agents targeting migraine and other neurological disorders. It is essential for pharmaceutical R&D laboratories and advanced chemical synthesis facilities focused on developing enantioselective processes and studying structure-activity relationships.

Application

• Pharmaceutical Reference Standard: Serves as a critical chiral reference material for analytical method development, validation, and quality control in API manufacturing.
• Active Pharmaceutical Ingredient (API) Research: Used as a key chiral building block in the research and development of new chemical entities and generic versions of triptan-class migraine medications.
• Metabolite & Impurity Synthesis: Employed in the synthesis of potential metabolites and process-related impurities for pharmacological and toxicological studies.
• Enantioselective Synthesis Studies: A vital compound for developing and optimizing asymmetric synthesis routes and chiral separation techniques.
• Biochemical & Pharmacological Research: Utilized in in-vitro and in-vivo studies to investigate the specific biological activity and receptor binding profile of the pure enantiomer.

Basic Information

Product Name	Ent-Eletriptan
CAS No.	1252673-29-2
Molecular Formula	C22H26N2O2S
Molecular Weight	382.52 g/mol
Synonyms	(R)-Eletriptan; (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole; UNII-3JX17P5K3C; Eletriptan R-enantiomer; (R)-Eletriptan Hydrobromide Related Substance; Ent-Eletriptan free base
EINECS	Contact for details

Quality Control

Our Ent-Eletriptan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. A detailed Certificate of Analysis (COA) providing results for assay, enantiomeric excess, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.