Description

tert-Butyl n-[3-Hydroxy-3-(Trifluoromethyl)Cyclobutyl]Carbamate is a high-value, multifunctional chemical intermediate featuring a cyclobutyl ring substituted with both a hydroxyl and a trifluoromethyl group, protected by a Boc (tert-butoxycarbonyl) group. This unique structure makes it a critical building block for medicinal chemistry, enabling the synthesis of novel compounds with enhanced metabolic stability and bioavailability. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing next-generation therapeutics, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Protease Inhibitor Synthesis: Serves as a crucial precursor in constructing advanced scaffolds for protease inhibitors, leveraging the cyclobutyl and trifluoromethyl motifs for potency and selectivity.
• Agrochemical Research: Used in the discovery of novel agrochemicals, where the trifluoromethyl group can impart favorable properties like improved lipophilicity and pest resistance management.
• Material Science Monomer: Potential application as a specialty monomer for synthesizing polymers with unique thermal and chemical resistance properties, thanks to the rigid cyclobutane core.
• Peptidomimetics & Bioisosteres: The Boc-protected amino-alcohol structure is ideal for creating peptidomimetics and non-natural amino acid analogs in drug discovery programs.
• Fluorine Chemistry Library Building: An essential component for constructing diverse compound libraries focused on fluorine-containing molecules for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl n-[3-Hydroxy-3-(Trifluoromethyl)Cyclobutyl]Carbamate
CAS No.	1251924-65-8
Molecular Formula	C10H16F3NO3
Molecular Weight	255.24 g/mol
Synonyms	1,1-Dimethylethyl N-[3-hydroxy-3-(trifluoromethyl)cyclobutyl]carbamate; tert-Butyl (3-hydroxy-3-(trifluoromethyl)cyclobutyl)carbamate; 3-((tert-Butoxycarbonyl)amino)-3-(trifluoromethyl)cyclobutanol; Boc-3-amino-3-(trifluoromethyl)cyclobutanol; (3-Hydroxy-3-(trifluoromethyl)cyclobutyl)carbamic acid tert-butyl ester; 3-(Boc-amino)-3-(trifluoromethyl)cyclobutanol; 3-(Trifluoromethyl)-3-((tert-butoxycarbonyl)amino)cyclobutanol
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[3-Hydroxy-3-(Trifluoromethyl)Cyclobutyl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request, ensuring traceability and regulatory compliance for global supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its chemical properties, the material should be kept away from strong alkalis and fluorides. For long-term storage, consider using an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.