Description

3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol is a high-value, functionalized cyclobutane derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both an amino group and a trifluoromethyl-substituted alcohol on a strained four-membered ring, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where its stereochemistry and fluorine content can significantly influence biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas like enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for specialty polymers to impart unique thermal or chemical resistance properties.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl motif into complex molecules in medicinal and materials chemistry.
• Academic and Contract Research: Utilized in university and CRO laboratories for methodological studies and the exploration of new chemical space.

Basic Information

Product Name	3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol
CAS No.	1251924-07-8
Molecular Formula	C5H8F3NO
Molecular Weight	155.12 g/mol
Synonyms	1-(Trifluoromethyl)cyclobutan-1-ol, 3-amino-; 3-Amino-1-(trifluoromethyl)cyclobutanol; 1-Cyclobutanol, 3-amino-1-(trifluoromethyl)-; 3-Amino-1-trifluoromethylcyclobutan-1-ol; (1r,3s)-3-Amino-1-(trifluoromethyl)cyclobutan-1-ol; (1s,3r)-3-Amino-1-(trifluoromethyl)cyclobutan-1-ol; 3-Azanyl-1-(trifluoromethyl)cyclobutan-1-ol
EINECS	Contact for details

Quality Control

Our 3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess (where applicable), and impurity profiles. Our quality commitment aligns with the standards expected in pharmaceutical and fine chemical sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.