Description

(1-Cyano-Cyclobutyl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutyl scaffold functionalized with cyano and protected carbamate groups. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and target selectivity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the construction of complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Protease Inhibitor Scaffold: The structural motif is valuable for developing inhibitors of various proteases, including serine and cysteine proteases.
• Peptidomimetic Chemistry: Used to introduce constrained, non-natural amino acid analogs into peptide chains to improve bioavailability and potency.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Acts as an intermediate in the development of new herbicides and pesticides with novel modes of action.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring rigid, functionalized monomers.

Basic Information

Product Name	(1-Cyano-Cyclobutyl)-Carbamic Acid tert-Butyl Ester
CAS No.	1251923-90-6
Molecular Formula	C10H16N2O2
Molecular Weight	196.25 g/mol
Synonyms	tert-Butyl N-(1-cyanocyclobutyl)carbamate; 1-Cyclobutyl-1-cyano-carbamic Acid tert-Butyl Ester; Boc-1-Cyano-cyclobutylamine; N-Boc-1-Aminocyclobutanecarbonitrile; 1-((tert-Butoxycarbonyl)amino)cyclobutanecarbonitrile; (1-Cyano-cyclobutyl)-carbamic acid 1,1-dimethylethyl ester; BOC-Cyclobutane-CN-NH2
EINECS	Contact for details

Quality Control

Every batch of (1-Cyano-Cyclobutyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical R&D. Our standard quality commitment includes HPLC purity ≥97% (typical), with identity confirmed by NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, impurities, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.