Description

(Alphas)-α-[[(tert-Butoxy)Carbonyl]Amino]-5-Pyrimidinepropanoic Acid is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a pyrimidine heterocycle. This compound is a critical building block in modern pharmaceutical research, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical developers working on novel drug candidates, particularly in the areas of protease inhibitors and nucleotide analogs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), especially for antiviral and anticancer therapies.
• Peptide Synthesis: Used as a protected amino acid analog in solid-phase and solution-phase peptide synthesis to introduce the pyrimidine moiety.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors targeting specific protease enzymes.
• Chemical Biology Research: Employed as a molecular probe or tool compound to study enzyme-substrate interactions and biological pathways.
• Nucleotide Analog Synthesis: Acts as a precursor in the creation of modified nucleosides and nucleotides for medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	(Alphas)-α-[[(tert-Butoxy)Carbonyl]Amino]-5-Pyrimidinepropanoic Acid
CAS No.	1251904-63-8
Molecular Formula	C₁₂H₁₉N₃O₅
Molecular Weight	285.30 g/mol
Synonyms	Boc-5-Pyrimidylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(5-pyrimidinyl)propanoic Acid; α-[(tert-Butoxycarbonyl)amino]-5-pyrimidinepropanoic Acid; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-pyrimidin-5-ylpropanoic Acid; 5-Pyrimidinepropanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-; Boc-Prm-OH; Boc-5-Prm-OH; (S)-3-(5-Pyrimidinyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid
EINECS	Contact for details

Quality Control

Our production of (Alphas)-α-[[(tert-Butoxy)Carbonyl]Amino]-5-Pyrimidinepropanoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.