Description

(S)-2-((tert-Butoxycarbonyl)Amino)-3-Morpholinopropanoic Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a morpholine moiety. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other therapeutic agents. It is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical industries who require high-quality, enantiomerically pure starting materials for peptide-mimetic drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, including HCV NS3/4A and HIV protease inhibitors.
• Peptidomimetic Drug Discovery: Used to incorporate constrained, non-proteinogenic amino acid structures into novel drug candidates to enhance metabolic stability and binding affinity.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex, target-oriented Active Pharmaceutical Ingredients.
• Chemical Biology Research: Employed in the design and synthesis of enzyme inhibitors, receptor ligands, and molecular probes for mechanistic studies.
• Asymmetric Synthesis: Utilized as a chiral pool reagent for the construction of stereochemically defined complex molecules in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: A fundamental component for CDMOs (Contract Development and Manufacturing Organizations) producing cGMP intermediates for clinical and commercial supply chains.

Basic Information

Product Name	(S)-2-((tert-Butoxycarbonyl)Amino)-3-Morpholinopropanoic Acid
CAS No.	1251904-26-3
Molecular Formula	C12H22N2O5
Molecular Weight	274.32 g/mol
Synonyms	Boc-L-Morpholinealanine; (S)-2-(Boc-Amino)-3-morpholinopropanoic acid; Boc-Morpholine-Ala-OH; (S)-3-Morpholino-2-((tert-butoxycarbonyl)amino)propanoic acid; N-Boc-3-morpholinyl-L-alanine; L-3-Morpholinylalanine, N-Boc-; Boc-L-3-Morpholinylalanine; Nα-Boc-3-morpholinyl-L-alanine
EINECS	Contact for details

Quality Control

Our (S)-2-((tert-Butoxycarbonyl)Amino)-3-Morpholinopropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and standard pharmacopeial methods for identity and assay. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics. Our quality commitment supports applications requiring cGMP compliance for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and/or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.