Description

Fmoc-3-(1-Morpholinyl)-L-Ala-Oh CAS NO 1251903-85-1 is a specialized, non-proteinogenic Fmoc-protected amino acid derivative. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a morpholine-modified alanine residue into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools. The unique morpholinyl side chain can impart specific conformational, solubility, or bioactivity properties to the target peptide sequence.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a protected amino acid building block for automated and manual peptide synthesis.
• Pharmaceutical Research: Synthesis of peptide drug candidates, including potential antimicrobial, hormonal, or receptor-targeting peptides.
• Chemical Biology Probes: Construction of labeled or modified peptides used to study protein-protein interactions and enzyme function.
• Peptide Library Production: A key component in combinatorial chemistry for creating diverse peptide libraries for screening.
• Conformationally Constrained Peptides: The morpholine moiety can be used to introduce structural constraints or modify the peptide backbone's physicochemical properties.
• Academic & Institutional Research: Fundamental research in peptide chemistry, medicinal chemistry, and biochemistry.

Basic Information

Product Name	Fmoc-3-(1-Morpholinyl)-L-Ala-Oh
CAS No.	1251903-85-1
Molecular Formula	C22H24N2O5
Molecular Weight	396.44 g/mol
Synonyms	Fmoc-3-Morpholino-L-alanine; Fmoc-L-3-(4-Morpholinyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(morpholin-4-yl)-L-alanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-morpholin-4-ylpropanoic acid; Fmoc-3-Mor-Ala-OH; Fmoc-3-(N-Morpholino)-L-alanine; Nα-Fmoc-3-(4-morpholinyl)-L-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-3-(1-Morpholinyl)-L-Ala-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.