Description

3'-Dechloro-3'-Bromo Bupropion Fumarate is a high-purity pharmaceutical intermediate and reference standard of significant importance in modern medicinal chemistry. This compound is critical for research and development activities focused on novel therapeutic agents, particularly in the central nervous system (CNS) domain. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for method development, impurity profiling, and synthesis pathway optimization.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis and research of novel bupropion analogs and related therapeutic compounds.
• Reference Standard: Used as a certified standard in analytical laboratories for method validation, quality control (QC), and impurity identification in API batches.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand drug disposition and activity.
• Process Chemistry R&D: Serves as a crucial reagent for developing and optimizing scalable synthetic routes for new chemical entities.
• Regulatory Compliance: Essential for preparing documentation and analytical data packages for regulatory submissions (e.g., FDA, EMA).
• Academic Research: Utilized in university and institutional research for studying structure-activity relationships (SAR) in medicinal chemistry projects.

Basic Information

Product Name	3'-Dechloro-3'-Bromo Bupropion Fumarate
CAS No.	1251850-99-3
Molecular Formula	C17H19BrClNO5
Molecular Weight	432.69 g/mol
Synonyms	Bupropion Impurity 12; Bupropion Related Compound H; 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone Fumarate; 3'-Chloro-3'-Bromo Bupropion Fumarate; (±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one (E)-but-2-enedioate; BW 323U Fumarate; Amfebutamone Impurity Fumarate
EINECS	Contact for details

Quality Control

Our 3'-Dechloro-3'-Bromo Bupropion Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material suitable for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The container should be kept tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.