Description

2-Oxazoleacetonitrile, 4-(1,1-Dimethylethyl)-α-[(4S)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-4,5-Dihydro-, (4S)- is a high-purity, stereochemically defined chiral building block. This compound matters for its critical role in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing sophisticated molecular architectures with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Potential building block for advanced functional materials and liquid crystals due to its rigid, heterocyclic structure.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic projects.

Basic Information

Item	Detail
Product Name	2-Oxazoleacetonitrile, 4-(1,1-Dimethylethyl)-α-[(4S)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-4,5-Dihydro-, (4S)-
CAS No.	1251471-84-7
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	(4S)-4-tert-Butyl-α-[(4S)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]-4,5-dihydro-1,3-oxazole-2-acetonitrile; (4S)-4-(tert-Butyl)-α-[(4S)-4-(tert-butyl)-4,5-dihydro-2-oxazolyl]-4,5-dihydro-2-oxazoleacetonitrile; Chiral Oxazole Nitrile Derivative; tert-Butyl Oxazole Acetonitrile; (S,S)-Oxazole Building Block; CAS 1251471-84-7
EINECS	Contact for details

Quality Control

Our 2-Oxazoleacetonitrile derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.