Description

2,2-Difluoro-2-(2-Fluorophenyl)Acetic Acid is a specialized fluorinated organic acid building block of significant interest in advanced chemical synthesis. Its value lies in the unique reactivity imparted by the difluoroacetic acid moiety adjacent to a fluorinated aromatic ring, making it a key intermediate for constructing complex molecules. This compound is primarily needed by research and development teams, as well as process chemists, in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Acts as a monomer or modifying agent in the development of specialty polymers and fluorinated materials with unique surface properties.
• Ligand and Catalyst Development: Employed in organic chemistry research to create novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies in fluorination and difluoromethylation reactions.
• Diagnostic Agent Synthesis: Potential intermediate in the development of fluorinated contrast agents or radiotracers for medical imaging (e.g., PET scans).

Basic Information

Product Name	2,2-Difluoro-2-(2-Fluorophenyl)Acetic Acid
CAS No.	1250779-80-6
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	2-(2-Fluorophenyl)-2,2-difluoroacetic Acid; α,α-Difluoro-2-fluorophenylacetic Acid; 2-Fluoro-α,α-difluorobenzeneacetic Acid; (2-Fluorophenyl)difluoroacetic Acid; Difluoro(2-fluorophenyl)acetic Acid; 2,2-Difluoro-2-(o-fluorophenyl)acetic Acid; 1250779-80-6; o-Fluorophenyl(difluoro)acetic Acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-(2-Fluorophenyl)Acetic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizers, and sources of ignition. Due to its acidic nature, ensure containers are made of compatible materials and are clearly labeled.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.