Description

Hydroxy-(2-Trifluoromethyl-Phenyl)-Acetic Acid Methyl Ester is a high-value fluorinated building block essential for advanced organic synthesis. This compound matters for its role in introducing the trifluoromethylphenyl pharmacophore, a key structural motif known to enhance metabolic stability and lipophilicity in active molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by fine chemical manufacturers producing specialized intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where fluorinated aromatic units modify physical properties.
• Custom Synthesis & Contract Manufacturing: A key building block for custom synthesis projects and scale-up services for clients in the life sciences sector.

Basic Information

Product Name	Hydroxy-(2-Trifluoromethyl-Phenyl)-Acetic Acid Methyl Ester
CAS No.	1250424-06-6
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	Methyl 2-Hydroxy-2-[2-(trifluoromethyl)phenyl]acetate; 2-Hydroxy-2-(2-trifluoromethylphenyl)acetic Acid Methyl Ester; α-Hydroxy-α-(2-trifluoromethylphenyl)acetic Acid Methyl Ester; Methyl (2-Hydroxy-2-(2-(trifluoromethyl)phenyl)acetate; Mandelic Acid, 2-(Trifluoromethyl)-, Methyl Ester; Methyl O-(2-Trifluoromethylphenyl)glycolate
EINECS	Contact for details

Quality Control

Our Hydroxy-(2-Trifluoromethyl-Phenyl)-Acetic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.