Description

5-Bromo-2-Fluoroisophthalonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its core value lies in its unique halogenated and fluorinated structure, which enables precise molecular modifications critical for developing novel compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require reliable, high-quality raw materials for their R&D and production processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for constructing complex ligands used in transition metal catalysis and asymmetric synthesis.
• Functional Material Precursor: Employed in the research and production of advanced materials, including liquid crystals, organic semiconductors, and polymers with specific electronic properties.
• Chemical Biology Probe Synthesis: Utilized to create tagged molecules and probes for studying biological mechanisms and drug-target interactions.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings, enabling complex molecular architecture assembly.

Basic Information

Product Name	5-Bromo-2-Fluoroisophthalonitrile
CAS No.	1250411-83-6
Molecular Formula	C8H2BrFN2
Molecular Weight	224.02 g/mol
Synonyms	2-Fluoro-5-bromoisophthalonitrile; 1-Bromo-3-cyano-5-fluorobenzene-2-carbonitrile; 5-Bromo-2-fluorobenzene-1,3-dicarbonitrile; Isophthalonitrile, 5-bromo-2-fluoro-; 1250411-83-6; 5-Br-2-F-isophthalonitrile
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoroisophthalonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards required for GMP intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.