Description

2,2-Difluoro-2-(2-Methylphenyl)Acetic Acid is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group adjacent to a carboxylic acid on an ortho-substituted phenyl ring, makes it a valuable precursor for creating novel compounds with enhanced properties. This high-purity intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors. It is used to introduce fluorine atoms into target molecules, a key strategy for modulating their metabolic stability, lipophilicity, and biological activity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drugs where fluorination is used to optimize pharmacokinetic profiles.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides, where the difluoroacetic acid moiety can contribute to improved efficacy and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Precursor: Employed in the research and development of advanced polymers and functional materials that require fluorinated aromatic components for specific thermal or chemical resistance.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research focused on exploring new methodologies in fluoroorganic chemistry and C-F bond formation.

Basic Information

Product Name	2,2-Difluoro-2-(2-Methylphenyl)Acetic Acid
CAS No.	1250354-50-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	2-(2-Methylphenyl)-2,2-difluoroacetic Acid; α,α-Difluoro-o-toluic Acid; 2-Methyl-α,α-difluorobenzeneacetic Acid; o-Tolyl(difluoro)acetic Acid; 2,2-Difluoro-2-(o-tolyl)acetic Acid; Difluoro(o-tolyl)acetic Acid; (2-Methylphenyl)difluoroacetic Acid
EINECS	Contact for details

Quality Control

Our production of 2,2-Difluoro-2-(2-Methylphenyl)Acetic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the exacting standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and physical characteristics. We are committed to consistent quality and supply reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.