Description

Ethyl 2-(3-Cyanophenyl)-2,2-Difluoroacetate is a high-purity fluorinated building block essential for advanced organic synthesis. This compound matters for its unique difluoroacetate ester moiety attached to a cyanophenyl core, enabling precise molecular modifications in complex chemical architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoroacetate group can contribute to improved activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging the cyanophenyl group for molecular alignment and the ester for polymerization.
• Fluorine Chemistry: An important reagent for introducing the -CHF2 or related fluorinated groups into target molecules via further chemical transformation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-value fluorinated intermediates.

Basic Information

Product Name	Ethyl 2-(3-Cyanophenyl)-2,2-Difluoroacetate
CAS No.	1249788-93-9
Molecular Formula	C11H9F2NO2
Molecular Weight	225.19 g/mol
Synonyms	2-(3-Cyanophenyl)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl 3-Cyano-α,α-difluorobenzeneacetate; Ethyl 2,2-Difluoro-2-(3-cyanophenyl)acetate; α,α-Difluoro-3-cyanobenzeneacetic Acid Ethyl Ester; 3-Cyanobenzylidene Fluoride Ethyl Ester (difluoro); Difluoro(3-cyanophenyl)acetic Acid Ethyl Ester; Ethyl α,α-Difluoro-3-cyanophenylacetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(3-Cyanophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.