Description

2,2-Difluoro-2-(4-Fluoro-3-Methylphenyl)Acetic Acid is a high-value fluorinated aromatic building block essential for advanced synthetic chemistry. Its unique difluoroacetic acid moiety attached to a substituted phenyl ring makes it a critical intermediate for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials. We supply this material with a focus on consistent high purity and reliable global supply chain logistics to support your most demanding projects.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of fluorinated drug candidates, particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides where the introduction of fluorine atoms improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized fluorinated ligands used in asymmetric catalysis and material science.
• Fluorinated Liquid Crystal & Polymer Research: Employed in the synthesis of monomers for advanced display materials and high-performance polymers.
• Chemical Biology & Proteomics: Utilized as a building block for activity-based probes and fluorinated tags in biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	2,2-Difluoro-2-(4-Fluoro-3-Methylphenyl)Acetic Acid
CAS No.	1249162-93-3
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	4-Fluoro-3-methyl-α,α-difluorobenzeneacetic acid; 2-(4-Fluoro-3-methylphenyl)-2,2-difluoroacetic acid; (4-Fluoro-3-methylphenyl)difluoroacetic acid; 2,2-Difluoro-2-(4-fluoro-3-methylphenyl)ethanoic acid; α,α-Difluoro-4-fluoro-3-methylbenzeneacetic acid; DFMPAA; 1249162-93-3 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-2-(4-Fluoro-3-Methylphenyl)Acetic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert atmosphere handling to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.