Description

4-(Maleimidomethyl)Benzonitrile is a high-purity, bifunctional chemical building block featuring both a maleimide and a benzonitrile group. This compound is critical for advanced bioconjugation and polymer chemistry, enabling the precise cross-linking and functionalization of biomolecules and synthetic polymers. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors who require reliable, high-quality intermediates for developing targeted therapeutics, biosensors, and specialty polymers.

Application

• Bioconjugation Reagent: For site-specific labeling of antibodies, proteins, peptides, and oligonucleotides via thiol-maleimide chemistry.
• Pharmaceutical Intermediate: In the synthesis of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Polymer Cross-Linking Agent: Used to create functional hydrogels, smart polymers, and biocompatible materials with tailored properties.
• Diagnostic Probe Synthesis: Building block for fluorescent probes, imaging agents, and biosensor components.
• Surface Functionalization: For modifying nanoparticles, chips, and other surfaces to create bioactive interfaces.
• Research & Development: A versatile tool in chemical biology and medicinal chemistry for exploring new bioconjugation strategies.

Basic Information

Product Name	4-(Maleimidomethyl)Benzonitrile
CAS No.	1249094-81-2
Molecular Formula	C12H8N2O2
Molecular Weight	212.21 g/mol
Synonyms	4-(Maleimidomethyl)benzonitrile; 4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-ylmethyl)benzonitrile; 1-(4-Cyanobenzyl)-1H-pyrrole-2,5-dione; Maleimidomethyl benzonitrile; 4-Maleimidomethylbenzonitrile; N-(4-Cyanobenzyl)maleimide; 4-(Maleimidomethyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-(Maleimidomethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.