Description

(2-Bromo-Phenyl)-Chloro-Acetonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromine and chlorine substituents on a phenylacetonitrile core, makes it a valuable precursor for constructing complex heterocycles and functionalized intermediates. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. Its reactivity profile enables key transformations, including nucleophilic substitutions and cyclization reactions, essential for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly for constructing fused-ring systems and introducing halogenated pharmacophores.
• Agrochemical Active Ingredient Development: Used in research to create new herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated aromatic compounds.
• Ligand and Catalyst Synthesis: Acts as a precursor for synthesizing specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs or conductive polymers, where halogenated units can tune electronic properties.
• Custom Chemical Synthesis: Provides a versatile starting point for contract research organizations (CROs) and fine chemical manufacturers producing bespoke compounds for client projects.

Basic Information

Product Name	(2-Bromo-Phenyl)-Chloro-Acetonitrile
CAS No.	1248448-76-1
Molecular Formula	C8H5BrClN
Molecular Weight	230.49 g/mol
Synonyms	2-Bromo-α-chlorobenzeneacetonitrile; (2-Bromophenyl)(chloro)acetonitrile; α-Chloro-2-bromobenzyl cyanide; 2-Bromobenzyl chloride cyanide; (o-Bromophenyl)chloroacetonitrile; 1-(2-Bromophenyl)-1-chloroacetonitrile; Chloro(2-bromophenyl)acetonitrile
EINECS	Contact for details

Quality Control

Every batch of (2-Bromo-Phenyl)-Chloro-Acetonitrile is manufactured and tested under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.