Description

2-[3-(2,2,2-Trifluoroethoxy)Phenyl]Acetic Acid is a high-value fluorinated aromatic building block, distinguished by the presence of a trifluoroethoxy substituent which imparts unique electronic and steric properties. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its structure is leveraged to modulate biological activity, metabolic stability, and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving charge transport and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, surface properties, and durability.
• Chemical Research & Development: A versatile reagent for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.
• Fluorinated Probe Development: Used in the synthesis of biochemical probes and imaging agents for 19F NMR spectroscopy and positron emission tomography (PET).

Basic Information

Product Name	2-[3-(2,2,2-Trifluoroethoxy)Phenyl]Acetic Acid
CAS No.	1248311-33-2
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	3-(2,2,2-Trifluoroethoxy)benzeneacetic Acid; [3-(2,2,2-Trifluoroethoxy)phenyl]acetic Acid; 2-(3-(2,2,2-Trifluoroethoxy)phenyl)acetic Acid; α-Carboxy-3-(2,2,2-trifluoroethoxy)toluene; 3-(Trifluoroethoxyl)phenylacetic Acid; TFEPA; TFE-PAA
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and manufacturing. We provide material with typical purity grades suitable for advanced R&D and process scale-up. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.