Description

Rac-Tolterodine-D14 Tartrate is a deuterium-labeled isotopologue of tolterodine, a well-known antimuscarinic agent. This high-purity reference standard is critical for ensuring analytical accuracy and reliability in quantitative mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and bioanalytical validation.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of tolterodine and its metabolites in complex biological matrices like plasma and urine.
• Bioanalytical Method Development & Validation: Essential for developing and validating robust, GLP-compliant analytical methods in support of preclinical and clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in absorption, distribution, metabolism, and excretion (ADME) research to track drug disposition.
• Pharmaceutical Quality Control: Acts as a reference material for impurity profiling and assay verification of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Clinical Toxicology: Enables accurate measurement of tolterodine levels in forensic analysis or therapeutic drug monitoring.

Basic Information

Product Name	Rac-Tolterodine-D14 Tartrate
CAS No.	1246911-91-0
Molecular Formula	C26H30D14NO7
Molecular Weight	~508.66 g/mol
Synonyms	(±)-Tolterodine-d14 Tartrate; Tolterodine (phenyl-d5, benzyl-d5, N-methyl-d3) Tartrate; 2-[(1R)-3-[Bis(1,1,2,2,2-pentadeuterioethyl)amino]-1-(4,5,6,7-tetradeuterio-1,2,3,4-tetrahydro-5-methyl-1-naphthalenyl)propyl]-4-methylphenol Tartrate; (R,S)-Tolterodine-d14 L-Tartrate; Tolterodine-d14 Hydrogen Tartrate; Detrol-d14 Tartrate
EINECS	Contact for details

Quality Control

Every batch of Rac-Tolterodine-D14 Tartrate is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for identity, purity (HPLC assay), isotopic enrichment, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.