Description

[2H4]-Zuclopenthixol Succinate Salt is a deuterium-labeled internal standard of the antipsychotic drug zuclopenthixol, essential for precise quantitative analysis in bioanalytical research. This high-purity reference material is critical for ensuring accuracy and reproducibility in pharmacokinetic and metabolism studies, providing a stable isotopic marker that minimizes analytical interference. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced method development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of zuclopenthixol in complex biological matrices like plasma, serum, and tissue homogenates via liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Forensic & Toxicological Analysis: Supports the accurate detection and measurement of zuclopenthixol in forensic toxicology cases and therapeutic drug monitoring (TDM) programs.
• Drug Impurity & Degradation Profiling: Aids in the identification and quantification of potential impurities or degradation products in pharmaceutical formulations.
• Stable Isotope Dilution Assays: Fundamental for isotope dilution mass spectrometry (IDMS) techniques, which are considered a gold standard for achieving high metrological accuracy.

Basic Information

Product Name	[2H4]-Zuclopenthixol Succinate Salt
CAS No.	1246833-97-5
Molecular Formula	C24H28D4ClN3O2S • C4H6O4
Molecular Weight	Contact for details
Synonyms	Deuterated Zuclopenthixol Succinate; Zuclopenthixol-d4 Succinate; (Z)-4-[3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol-d4 Succinate Salt; cis(Z)-Clopenthixol-d4 Succinate; cis(Z)-Clopenthixol Diacetate-d4 (common misnomer); Clopixol-d4 (labeled analog); Internal Standard for Zuclopenthixol; Zuclopenthixol D4 Succinate
EINECS	Contact for details

Quality Control

Every batch of [2H4]-Zuclopenthixol Succinate Salt is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for isotopic purity, chemical purity, and stability. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.