Description

Carboxy Terbinafine-D7 is a high-purity, deuterium-labeled derivative of the active metabolite of terbinafine, a widely used antifungal agent. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in quantitative bioanalytical studies, particularly in pharmacokinetic and metabolism research. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug development and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of terbinafine and its metabolites in biological matrices (plasma, serum, tissue) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the biotransformation pathways of terbinafine.
• Forensic and Clinical Toxicology: Supports the development and validation of highly specific and sensitive analytical methods for therapeutic drug monitoring and forensic analysis.
• Method Development & Validation: A key reagent for developing, optimizing, and validating robust bioanalytical assays in compliance with regulatory guidelines (e.g., FDA, EMA).
• Reference Material: Acts as a certified reference material (CRM) for calibrating instruments and ensuring data integrity in GLP/GMP-compliant laboratories.

Basic Information

Product Name	Carboxy Terbinafine-D7
CAS No.	1246833-21-5
Molecular Formula	C21H18D7NO2
Molecular Weight	~327.5 g/mol
Synonyms	(E)-N-(6,6-Dimethylhept-2-en-4-yn-1-yl)-N-methyl-1-naphthalenemethanamine-α,α,β,β,γ,γ,γ-D7-carboxylic Acid; Terbinafine Carboxylic Acid-D7; Terbinafine Acid Metabolite-D7; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine-α,α,β,β,γ,γ,γ-D7-carboxylic Acid; TBF-COOH-D7; Deuterated Carboxy Terbinafine
EINECS	Contact for details

Quality Control

Every batch of Carboxy Terbinafine-D7 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and include detailed results for identity, purity (HPLC), isotopic enrichment, and specific tests for residual solvents and impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Store in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.