Description

(E/Z)-4,4’-Dihydroxy-n-Desmethyl Tamoxifen-D3 is a deuterated analog of a key tamoxifen metabolite, designed for use as a high-purity internal standard in analytical chemistry. This compound is critical for ensuring accurate quantification and method validation in complex biological matrices, providing superior data integrity for research and quality control. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers engaged in bioanalytical method development, pharmacokinetic studies, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the precise quantification of tamoxifen and its metabolites in plasma, serum, and tissue samples.
• Pharmacokinetic and Bioequivalence Studies: Used to track drug absorption, distribution, metabolism, and excretion (ADME) with high specificity.
• Therapeutic Drug Monitoring (TDM): Enables accurate measurement of drug concentrations in patients to optimize dosing regimens and minimize side effects.
• Biomarker Research: Supports investigations into endocrine response and resistance mechanisms in cancer research.
• Method Development and Validation: Serves as a critical reference material to establish selectivity, accuracy, and precision of new analytical methods.
• Quality Control in Clinical Laboratories: Ensures the reliability and reproducibility of diagnostic and monitoring assays.

Basic Information

Product Name	(E/Z)-4,4’-Dihydroxy-n-Desmethyl Tamoxifen-D3
CAS No.	1246832-93-8
Molecular Formula	C25H26D3NO2
Molecular Weight	~379.5 g/mol
Synonyms	4-Hydroxy-N-desmethyltamoxifen-d3; Endoxifen-d3; (Z)-4-Hydroxy-N-desmethyltamoxifen-d3; (E)-4-Hydroxy-N-desmethyltamoxifen-d3; 4-OH-ND-Tam-D3; Deuterated Endoxifen; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene-d3; FC-1271a-d3 (related metabolite)
EINECS	Contact for details

Quality Control

Every batch of (E/Z)-4,4’-Dihydroxy-n-Desmethyl Tamoxifen-D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity as verified by advanced chromatographic and spectrometric techniques. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, isotopic enrichment, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.