Description

Sotalol D6 Hcl CAS NO 1246820-85-8 is a deuterium-labeled isotopologue of the β-blocker sotalol hydrochloride, serving as a critical internal standard for precise quantitative analysis. This high-purity reference material is essential for ensuring accuracy and reliability in sensitive analytical methods, particularly in regulated environments. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and bioequivalence testing.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a stable isotope-labeled internal standard for the accurate quantification of sotalol in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Metabolism and Pharmacokinetic (PK/PD) Studies: Enables precise tracking and measurement of drug concentration over time, crucial for ADME (Absorption, Distribution, Metabolism, Excretion) profiling.
• Bioanalytical Method Development and Validation: Provides a critical component for developing robust, selective, and sensitive HPLC or UPLC methods coupled with mass spectrometry.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies requiring high-accuracy measurement of sotalol levels in patient samples for efficacy and safety assessments.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and assay development for sotalol hydrochloride active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Toxicology Analysis: Aids in the definitive identification and quantification of sotalol in forensic investigations.

Basic Information

Product Name	Sotalol D6 Hcl
CAS No.	1246820-85-8
Molecular Formula	C12H14D6ClN2O3S•HCl
Molecular Weight	349.30 g/mol (approx.)
Synonyms	N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide-d6 hydrochloride; Sotalol-d6 hydrochloride; Sotalol (hexadeuterated) hydrochloride; (RS)-Sotalol-d6 HCl; MJ 1999-d6 HCl; β-Cardone-d6 HCl; Sotacor-d6 HCl
EINECS	Contact for details

Quality Control

Our Sotalol D6 Hcl is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for critical parameters including isotopic purity (D-enrichment), chemical purity (by HPLC), and identification. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.