Description

Losartan-D4 Carboxylic Acid is a high-purity, stable isotope-labeled analog of the Losartan metabolite, Losartan Carboxylic Acid. This deuterated compound is an essential reference standard and internal standard for the precise quantification of Losartan and its active metabolite in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and bioanalytical validation.

Application

• Bioanalytical Reference Standard: Serves as a critical internal standard in LC-MS/MS and HPLC methods for accurate quantification of Losartan and its active metabolite in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Used to develop, optimize, and validate robust analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Doping Control & Forensic Analysis: Employed in sports anti-doping laboratories and forensic toxicology for the definitive identification and quantification of Losartan.
• Pharmaceutical Quality Control: Supports impurity profiling and stability testing of Losartan-based drug products and active pharmaceutical ingredients (APIs).
• Isotope Dilution Mass Spectrometry (IDMS): Provides the highest accuracy in quantitative mass spectrometry applications due to its nearly identical chemical properties with the analyte.

Basic Information

Product Name	Losartan-D4 Carboxylic Acid
CAS No.	1246820-62-1
Molecular Formula	C22H19D4ClN6O3
Molecular Weight	447.93 g/mol
Synonyms	2-Butyl-5-chloro-3-[[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-(D4)]-1,3-diazaspiro[4.4]non-1-en-4-one; EXP 3174-D4; Losartan Carboxylic Acid-d4; Losartan Active Metabolite-d4; (2-Butyl-5-chloro-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4H-1,2,4-triazol-4-one-d4); 5-(4'-(4,5-Dihydro-5-(D4)-4-oxo-2-butyl-5-chloro-1H-imidazol-1-ylmethyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole
EINECS	Contact for details

Quality Control

Our Losartan-D4 Carboxylic Acid is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and MS. We ensure compliance with relevant guidelines for reference standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.