Description

2H-2-Ethyl-D5 Candesartan is a deuterated isotopologue of the active pharmaceutical ingredient Candesartan, a potent angiotensin II receptor blocker (ARB). This labeled compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, such as LC-MS/MS, ensuring high accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D, clinical research laboratories, and contract research organizations (CROs) focused on cardiovascular drug development and analysis.

Application

• Primary use as a stable isotope-labeled internal standard for the precise quantification of Candesartan in biological matrices (e.g., plasma, serum, urine) via mass spectrometry.
• Critical component in pharmacokinetic (PK) and bioavailability studies for generic and novel ARB drug formulations.
• Enabling drug metabolism and disposition (DMPK) research, including metabolite identification and profiling.
• Supporting clinical trial analysis to monitor drug concentration levels in patients.
• Quality control and method validation in bioanalytical laboratories and CROs.
• Use in forensic and anti-doping analysis for the detection of ARB-class substances.

Basic Information

Product Name	2H-2-Ethyl-D5 Candesartan
CAS No.	1246820-58-5
Molecular Formula	C24H15D5N6O3
Molecular Weight	~ 435.46 g/mol
Synonyms	Candesartan-d5 (2-ethyl-d5); (2-Ethyl-D5)-Candesartan; 2H-2-Ethyl-D5 Candesartan Cilexetil Impurity; 2-Ethyl-1,1,2,2,2-pentadeuterio Candesartan; TC-D5 Candesartan; Deuterated Candesartan Internal Standard; (±)-1-Hydroxyethyl 2-ethoxy-1-[[2'-(2H5-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate; BLNP-D5 Candesartan
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and tested to meet the exacting requirements of analytical research. We guarantee high chemical and isotopic purity confirmed by advanced techniques including NMR (¹H, ²H) and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and chromatographic data. Our quality system is designed to support GMP/GLP-compliant research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (²H NMR/MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.