Description

Carbutamide-D9 is a deuterated analog of the first-generation sulfonylurea drug, Carbutamide, specifically labeled with nine deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise quantification and pharmacokinetic analysis of Carbutamide in complex biological matrices using advanced techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors, ensuring accurate and reliable data for drug development and bioanalytical studies.

Application

• Primary use as an internal standard for the bioanalytical quantification of Carbutamide via LC-MS/MS and GC-MS.
• Metabolic and pharmacokinetic (PK/PD) studies in pharmaceutical research and development.
• Drug metabolism and disposition (DMPK) analysis to understand the fate of Carbutamide in biological systems.
• Quality control and method validation in clinical and forensic toxicology laboratories.
• Use in stable isotope dilution assays to achieve high accuracy and precision in quantitative mass spectrometry.
• Research into the mechanisms of sulfonylurea drugs and their isotopic effects.

Basic Information

Product Name	Carbutamide-D9
CAS No.	1246820-50-7
Molecular Formula	C11H8D9N3O3S
Molecular Weight	Approx. 284.36 g/mol
Synonyms	1-Butyl-3-(p-aminobenzenesulfonyl)urea-D9; N-[(Aminophenyl)sulfonyl]-N'-butylurea-D9; BZ-55-D9; U-6987-D9; Carbutamide (phenyl-D5, butyl-D4); Carbutamide-d9; Deuterated Carbutamide
EINECS	Contact for details

Quality Control

Our Carbutamide-D9 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for isotopic purity, chemical purity, and residual solvents, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.