Description

2-Desethoxy-2-Hydroxy-2H-2-Ethyl Candesartan Cilexetil-D5 is a deuterated analog of a key intermediate used in the synthesis of the antihypertensive drug Candesartan. This high-purity compound is essential for pharmaceutical research and development, particularly in the creation of deuterated drug candidates and as a critical reference standard. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for method development, pharmacokinetic studies, and quality control.

Application

• Deuterated Drug Synthesis: A key building block for the development of deuterium-labeled versions of Candesartan, which can offer improved metabolic stability and pharmacokinetic profiles.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification and quantification of related substances in active pharmaceutical ingredient (API) batches.
• Metabolite Studies: Used in mass spectrometry as an internal standard for the accurate analysis of Candesartan and its metabolites in biological matrices.
• Process Chemistry R&D: Employed in route scouting and optimization for the synthesis of Candesartan cilexetil and its derivatives.
• Analytical Method Development: Critical for developing and validating HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Stability Testing: Used to monitor degradation pathways and establish impurity profiles during drug product stability studies.

Basic Information

Item	Detail
Product Name	2-Desethoxy-2-Hydroxy-2H-2-Ethyl Candesartan Cilexetil-D5
CAS No.	1246820-36-9
Molecular Formula	C33H29D5N6O6
Molecular Weight	Contact for details
Synonyms	2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil-d5; Candesartan Cilexetil Deuterated Impurity; Candesartan Cilexetil-d5 Intermediate; 2-Desethoxy-2-hydroxy Candesartan Cilexetil Deuterated Analog; (2-Ethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-5-oxo-1-[[(cyclohexyloxy)carbonyl]oxy]pentyl-d5)benzoic Acid Derivative; TCV-116-d5 Related Compound; Deuterated Candesartan Impurity F; BP-461-d5
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediates are manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR)	≥ 95 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.